The Zeugma Hotel is located in the Sultanahmet district, within walking distance from the Hagia Sofia, Blue Mosque, Topkapi Palace Museum, Grand Bazaar, Spice Market, Basilica Cistern and the Byzantine Hippodrome. The cruise ship terminal and railway station of the Orient Express are a few minutes away.

The theme at this small, middle-end boutique hotel housed in a restored 19th-century Ottoman house is ancient Rome, with reproductions of mosaics discovered at the site of Zeugma decorating the walls.

All of the rooms are tastefully decorated and essentially the same clean, bright, and functional, with cabin showers and parquet flooring. Windows are double-glazed to keep out the sounds of night time revellers across the street. The staff will do their utmost to ensure that the guests enjoy a pleasant and memorable stay in this wonderful city. All rooms include a private bathroom with shower and hairdryer, individually controlled air conditioning, direct dial phone and satellite television.